12.9.11
發光貓和梅奧診所抗擊愛滋病等疾病
Mayo Clinic researchers have developed a genome-based immunization strategy to fight feline AIDS and illuminate ways to combat human HIV/AIDS and other diseases.
Credit: Mayo Clinic
Mayo Clinic researchers have developed a genome-based immunization strategy to fight feline AIDS and illuminate ways to combat human HIV/AIDS and other diseases. The goal is to create cats with intrinsic immunity to the feline AIDS virus. The findings -- called fascinating and landmark by one reviewer -- appear in the current online issue of Nature Methods.
Feline immunodeficiency virus (FIV) causes AIDS in cats as the human immunodeficiency virus (HIV) does in people: by depleting the body's infection-fighting T-cells. The feline and human versions of key proteins that potently defend mammals against virus invasion -- termed restriction factors -- are ineffective against FIV and HIV respectively. The Mayo team of physicians, virologists, veterinarians and gene therapy researchers, along with collaborators in Japan, sought to mimic the way evolution normally gives rise over vast time spans to protective protein versions. They devised a way to insert effective monkey versions of them into the cat genome.
"One of the best things about this biomedical research is that it is aimed at benefiting both human and feline health," says Eric Poeschla, M.D., Mayo molecular biologist and leader of the international study. "It can help cats as much as people."
Dr. Poeschla treats patients with HIV and researches how the virus replicates. HIV/AIDS has killed over 30 million people and left countless children orphaned, with no effective vaccine on the horizon. Less well known is that millions of cats also suffer and die from FIV/AIDS each year. Since the project concerns ways introduced genes can protect species against viruses, the knowledge and technology it produces might eventually assist conservation of wild feline species, all 36 of which are endangered.
The technique is called gamete-targeted lentiviral transgenesis -- essentially, inserting genes into feline oocytes (eggs) before sperm fertilization. Succeeding with it for the first time in a carnivore, the team inserted a gene for a rhesus macaque restriction factor known to block cell infection by FIV, as well as a jellyfish gene for tracking purposes. The latter makes the offspring cats glow green.
The macaque restriction factor, TRIMCyp, blocks FIV by attacking and disabling the virus's outer shield as it tries to invade a cell. The researchers know that works well in a culture dish and want to determine how it will work in vivo. This specific transgenesis (genome modification) approach will not be used directly for treating people with HIV or cats with FIV, but it will help medical and veterinary researchers understand how restriction factors can be used to advance gene therapy for AIDS caused by either virus.
The method for inserting genes into the feline genome is highly efficient, so that virtually all offspring have the genes. And the defense proteins are made throughout the cat's body. The cats with the protective genes are thriving and have produced kittens whose cells make the proteins, thus proving that the inserted genes remain active in successive generations.
The other researchers are Pimprapar Wongsrikeao, D.V.M., Ph.D.; Dyana Saenz, Ph.D.; and Tommy Rinkoski, all of Mayo Clinic; and Takeshige Otoi, Ph.D., of Yamaguchi University, Japan. The research was supported by Mayo Clinic and the Helen C. Levitt Foundation. Grants from the National Institutes of Health supported key prior technology developments in the laboratory.
Contacts and sources:
Mayo Clinic researchers have developed a genome-based immunization strategy to fight feline AIDS and illuminate ways to combat human HIV/AIDS and other diseases. The goal is to create cats with intrinsic immunity to the feline AIDS virus. The findings -- called fascinating and landmark by one reviewer -- appear in the current online issue of Nature Methods.
Feline immunodeficiency virus (FIV) causes AIDS in cats as the human immunodeficiency virus (HIV) does in people: by depleting the body's infection-fighting T-cells. The feline and human versions of key proteins that potently defend mammals against virus invasion -- termed restriction factors -- are ineffective against FIV and HIV respectively. The Mayo team of physicians, virologists, veterinarians and gene therapy researchers, along with collaborators in Japan, sought to mimic the way evolution normally gives rise over vast time spans to protective protein versions. They devised a way to insert effective monkey versions of them into the cat genome.
"One of the best things about this biomedical research is that it is aimed at benefiting both human and feline health," says Eric Poeschla, M.D., Mayo molecular biologist and leader of the international study. "It can help cats as much as people."
Dr. Poeschla treats patients with HIV and researches how the virus replicates. HIV/AIDS has killed over 30 million people and left countless children orphaned, with no effective vaccine on the horizon. Less well known is that millions of cats also suffer and die from FIV/AIDS each year. Since the project concerns ways introduced genes can protect species against viruses, the knowledge and technology it produces might eventually assist conservation of wild feline species, all 36 of which are endangered.
The technique is called gamete-targeted lentiviral transgenesis -- essentially, inserting genes into feline oocytes (eggs) before sperm fertilization. Succeeding with it for the first time in a carnivore, the team inserted a gene for a rhesus macaque restriction factor known to block cell infection by FIV, as well as a jellyfish gene for tracking purposes. The latter makes the offspring cats glow green.
The macaque restriction factor, TRIMCyp, blocks FIV by attacking and disabling the virus's outer shield as it tries to invade a cell. The researchers know that works well in a culture dish and want to determine how it will work in vivo. This specific transgenesis (genome modification) approach will not be used directly for treating people with HIV or cats with FIV, but it will help medical and veterinary researchers understand how restriction factors can be used to advance gene therapy for AIDS caused by either virus.
The method for inserting genes into the feline genome is highly efficient, so that virtually all offspring have the genes. And the defense proteins are made throughout the cat's body. The cats with the protective genes are thriving and have produced kittens whose cells make the proteins, thus proving that the inserted genes remain active in successive generations.
The other researchers are Pimprapar Wongsrikeao, D.V.M., Ph.D.; Dyana Saenz, Ph.D.; and Tommy Rinkoski, all of Mayo Clinic; and Takeshige Otoi, Ph.D., of Yamaguchi University, Japan. The research was supported by Mayo Clinic and the Helen C. Levitt Foundation. Grants from the National Institutes of Health supported key prior technology developments in the laboratory.
Contacts and sources:
微波武器和EMP殺死海軍陸戰隊員
www.veteranstoday.com/2011/08/10/microwave-weapon-and-emp-killed-marines/comment-page-1/
By: Tom Valentine
Date: 2011-08-10
This is a saga of death and deceit that was buried down Orwell’s memory hole like cat shit in a litterbox—The American way.
Despite valiant efforts by a qualified citizen who was first on the scene of a Presidential helicopter crash in Maryland woods near DC on May 19, 1993, is a story with ramifications today for readers and responders here at VT.
We not only have helicopters crashing with Marines or Seals in them, but in discussions of Distance Energy Weapons possibly used in the 9-11 blasts. Allow me to expand:
Have any of you veterans ever heard of the Harry Diamond Labs; Field test area, Blossom Point, MD? See
Data on Harry at Wikipedia.
That facility tested high voltage EMP (electromagnetic pulse) weapons and projected microwave technology.
When the Black hawk crashed it was in a wooded area, and the men who died in it were Capt. Scott Reynolds, Sgt. Brian Haney, Sgt. Tim Sable, and the pilot Maj. William Barkley.
The only reason this much is known is because a local archeologist with investigative experience, happened to see the chopper go down near Nanjemoy creek, and rushed to the scene.
Frank Owens said that he held the pilot’s hand and said a prayer while awaiting a response team from nearby Quantico Marine base. The bodies appeared “cooked” to him.
Owens smelled cover-up virtually the first week after, and commenced a serious effort to make the government own up. He called Radio Free America and we heard the story; A year later He also called G. Gordon Liddy’s show to get the word out. Liddy is credited with making an effort to blow the whistle. I did not give it the effort it deserved, though I stayed in touch with Owens for a long time after.
The local newspapers, The La Plata Indian Head Ledger and the St. Mary’s Today gave the story of Owens attempts to expose the fact our own government’s toys killed the crew, but the local news, despite being close to the seats of power, did not reach far.
Owens finally tried a weird plan to tell the story to the world; he agreed to work with Craig J. Coley, an engineer familiar with DEW, who commenced writing a novel in order to outline the “national security” expose. Coley wrote a detailed summary of the events and mailed me a copy.
In short, he told how Owens watched television broadcasts about the crash for a week or so, then became more suspicious that things were deliberately left out. It was at that point that Owens met Matt Barkley, the pilot’s brother, and agreed to help the family make a small monument at the site. Going back to the scene, Owens saw “hundreds” of fragments of the wreckage were still strewn in the vicinity. His previous experience told him that the military had been sloppy about policing what must have been classified equipment and so forth.
He opened his own investigation, collecting parts and photo-cataloging them. He already had photos of the bodies in his possession.
Owens quickly ruled out that any explosive device caused the crash and this was perplexing, then by serendipity he read an article about the loss of several Black hawks in Alabama. The suspected cause was EMP. EMP is known to disrupt all kinds of electronics and in 1993 it was not new. Israeli military is said to have used it to stop Egyptian equipment in the 1967 war. Owens learned that a Harry Diamond facility in Virginia was known to have EMP simulators. The information piqued his thinking—he knew that a Harry Diamond lab was located only seven miles from the crash site.
Owens naively stuck his nose into the facility, talking to employees, etc. He quickly drew fire in the form of harassment where he was charged as a spy and had one helluva time, and he wisely backed off.
Senator Boxer, D-calif. picked up the story as did USA Today reporters, but I’ve never seen clippings.
Coley, said that he would write in the novel how the DEA could use such weapons to wipe out drug gangs in Mexico. Fine and dandy; Coley thinks the DEA really wants to stop drug flow. He also suggested the government could use them on “The Michigan Militia,” which was bigger time in RFA days.
I have no info on EMP, but I learned a lot about microwaves researching the cooking and food aspects, written extensively in VT earlier. Microwaves react with water molecules. Snapping them back and forth millions or more times per second. It is this friction that generates the instant heat.
The human body is about 70 percent water, so microwave cooking would be a snap, so to speak. In 2001, the Air Force announced they had a “crowd control weapon that “burned” the skin but did not kill people protesting government. Recently, I suggested that such microwaves from DEW equipment could easily have been used to enhance the power of the thermite plus conventional explosives used to turn the towers into fine dust. Just add a little water to the target.
The article is reproduced in accordance with Section 107 of title 17 of the Copyright Law of the United States relating to fair-use and is for the purposes of criticism, comment, news reporting, teaching, scholarship, and research.
By: Tom Valentine
Date: 2011-08-10
This is a saga of death and deceit that was buried down Orwell’s memory hole like cat shit in a litterbox—The American way.
Despite valiant efforts by a qualified citizen who was first on the scene of a Presidential helicopter crash in Maryland woods near DC on May 19, 1993, is a story with ramifications today for readers and responders here at VT.
We not only have helicopters crashing with Marines or Seals in them, but in discussions of Distance Energy Weapons possibly used in the 9-11 blasts. Allow me to expand:
Have any of you veterans ever heard of the Harry Diamond Labs; Field test area, Blossom Point, MD? See
Data on Harry at Wikipedia.
That facility tested high voltage EMP (electromagnetic pulse) weapons and projected microwave technology.
When the Black hawk crashed it was in a wooded area, and the men who died in it were Capt. Scott Reynolds, Sgt. Brian Haney, Sgt. Tim Sable, and the pilot Maj. William Barkley.
The only reason this much is known is because a local archeologist with investigative experience, happened to see the chopper go down near Nanjemoy creek, and rushed to the scene.
Frank Owens said that he held the pilot’s hand and said a prayer while awaiting a response team from nearby Quantico Marine base. The bodies appeared “cooked” to him.
Owens smelled cover-up virtually the first week after, and commenced a serious effort to make the government own up. He called Radio Free America and we heard the story; A year later He also called G. Gordon Liddy’s show to get the word out. Liddy is credited with making an effort to blow the whistle. I did not give it the effort it deserved, though I stayed in touch with Owens for a long time after.
The local newspapers, The La Plata Indian Head Ledger and the St. Mary’s Today gave the story of Owens attempts to expose the fact our own government’s toys killed the crew, but the local news, despite being close to the seats of power, did not reach far.
Owens finally tried a weird plan to tell the story to the world; he agreed to work with Craig J. Coley, an engineer familiar with DEW, who commenced writing a novel in order to outline the “national security” expose. Coley wrote a detailed summary of the events and mailed me a copy.
In short, he told how Owens watched television broadcasts about the crash for a week or so, then became more suspicious that things were deliberately left out. It was at that point that Owens met Matt Barkley, the pilot’s brother, and agreed to help the family make a small monument at the site. Going back to the scene, Owens saw “hundreds” of fragments of the wreckage were still strewn in the vicinity. His previous experience told him that the military had been sloppy about policing what must have been classified equipment and so forth.
He opened his own investigation, collecting parts and photo-cataloging them. He already had photos of the bodies in his possession.
Owens quickly ruled out that any explosive device caused the crash and this was perplexing, then by serendipity he read an article about the loss of several Black hawks in Alabama. The suspected cause was EMP. EMP is known to disrupt all kinds of electronics and in 1993 it was not new. Israeli military is said to have used it to stop Egyptian equipment in the 1967 war. Owens learned that a Harry Diamond facility in Virginia was known to have EMP simulators. The information piqued his thinking—he knew that a Harry Diamond lab was located only seven miles from the crash site.
Owens naively stuck his nose into the facility, talking to employees, etc. He quickly drew fire in the form of harassment where he was charged as a spy and had one helluva time, and he wisely backed off.
Senator Boxer, D-calif. picked up the story as did USA Today reporters, but I’ve never seen clippings.
Coley, said that he would write in the novel how the DEA could use such weapons to wipe out drug gangs in Mexico. Fine and dandy; Coley thinks the DEA really wants to stop drug flow. He also suggested the government could use them on “The Michigan Militia,” which was bigger time in RFA days.
I have no info on EMP, but I learned a lot about microwaves researching the cooking and food aspects, written extensively in VT earlier. Microwaves react with water molecules. Snapping them back and forth millions or more times per second. It is this friction that generates the instant heat.
The human body is about 70 percent water, so microwave cooking would be a snap, so to speak. In 2001, the Air Force announced they had a “crowd control weapon that “burned” the skin but did not kill people protesting government. Recently, I suggested that such microwaves from DEW equipment could easily have been used to enhance the power of the thermite plus conventional explosives used to turn the towers into fine dust. Just add a little water to the target.
The article is reproduced in accordance with Section 107 of title 17 of the Copyright Law of the United States relating to fair-use and is for the purposes of criticism, comment, news reporting, teaching, scholarship, and research.
富爾福德：撒旦驚天動地的威脅令到舊金山和大馬士革“不適合人類居住”
2011年9月9日 18:53:08
The criminal cabal that has seized power in the G5 countries has reacted with new threats of mass terror to the concerted efforts by the nations and people of the world to remove them from power.
The latest threat, made by phone to a White Dragon Society member by some people who hid their identity, was that San Francisco and Damascus would be made “uninhabitable.” In reaction to this, a source contacted the White Dragon Society and promised that the entire extended families of any ruling bloodline found to be participating in genocide would be hunted down and exterminated down to the last individual. The source was not affiliated with the White Dragon Society but, they made it clear they that this threat was to be taken “very seriously.”
The repercussions of the secret late August meeting of financial representatives from 57 nations, meanwhile, continued to be felt last week. The criminal cabal that controls the Federal Reserve Board was engaged in a futile witch hunt trying to find who the participants were and what was discussed at the meeting. They are unlikely to find out much more than has been reported in this newsletter. That is to say White Dragon allies in the pentagon and US and world police agencies have access to the codes for the global collateral accounts. If necessary they will reveal who has accessed the world’s monetary assets for the past 60 years and what they spent that money on.
However, they would rather concentrate on the future and are still open to deals and compromises so long as the bottom line is that a major campaign to end poverty, end war and stop environmental destruction is agreed to. The window of opportunity is fast closing now, and the guiltiest cabal members are probably now certain to face prison time or worse.
There is also a need here to make a correction from last week’s report. It turns out that a representative from Canada (this writer’s native land) was present at the 57-member Monaco meeting. He said Canada is a small country (in terms of population) that has to pretend to go along with whoever is formally in power in the G5 but that the Canadian power structure was full of White Dragon sympathizers.
There has also been more confirmation from CIA and pentagon sources that there was indeed an attack on two major underground facilities controlled by the cabal in the US. The food, gold and weapons depot the cabal had near Washington D.C. was destroyed in an atomic blast, these sources now confirm. The nature of the second attack remains uncertain but two sources say it was the cabal’s underground facilities near Denver, Colorado that were destroyed. The people behind this attack have detailed maps of the US underground base and tunnel network and have promised more attacks if necessary to prevent the planned murder of 85% of humanity.
There are plenty of signs for all to see now that the criminal cabal that controls the G5 countries is on the ropes.
In the US, of course the 10th anniversary of the 911 terror attacks is coming and the perpetrators of this attack know that the world’s governments, military forces and intelligentsia know that it was a high level cabal in the G5 governments that was behind the attack. MORE HERE
source:
http://beforeitsnews.com/story/1073/210/Fulford:_Satanic_Cabal_Threatens_To_Make_San_Francisco_and_Damascus_Uninhabitable.html
福島能源部說華盛頓州輻射水平正常是正常的10萬倍
The amount of radiation released during the Fukushima nuclear disaster was so great that the level of atmospheric radioactive aerosols in Washington state was 10,000 to 100,000 times greater than normal levels in the week following the March 11 earthquake and tsunami that triggered the disaster.
Despite the increase, the levels were still well below the amount considered harmful to humans and they posed no health risks to residents at the time, according to researchers at The University of Texas at Austin.
The findings, published by a mechanical engineering professor at the Cockrell School of Engineering and researchers at Pacific Northwest National Laboratory (PNNL), provide important insight into the magnitude of the disaster. They also demonstrate huge advancements in the technology that's used for monitoring nuclear material and detecting covert nuclear operations around the world.
Despite the increase, the levels were still well below the amount considered harmful to humans and they posed no health risks to residents at the time, according to researchers at The University of Texas at Austin.
The findings, published by a mechanical engineering professor at the Cockrell School of Engineering and researchers at Pacific Northwest National Laboratory (PNNL), provide important insight into the magnitude of the disaster. They also demonstrate huge advancements in the technology that's used for monitoring nuclear material and detecting covert nuclear operations around the world.
Damaged reactor
Credit: Wikipedia
"I think the conclusion was that this was a really major event here," Cockrell School of Engineering Associate Professor Steven Biegalski said of the Fukushima disaster.
Biegalski was on a faculty research assignment at PNNL in Richland, Washington. Its here that, using technology that Biegalski helped improve, he and a team of researchers were the first to detect radioactive materials from Fukushima in the U.S.
The material detected, Xenon 133, is of the same chemical family as helium and argon and is an inert gas, meaning it does not react with other chemicals. The gas is not harmful in small doses and is used medically to study the flow of blood through the brain and the flow of air through the lungs.
Tracy Tipping, a health physicist and laboratory manager at The University of Texas at Austin's Nuclear Engineering Teaching Laboratory, said the average person in the U.S. receives about 16.4 microsieverts of radiation dose per day from various sources of naturally occurring radiation, such as radioactive materials in the soil, cosmic radiation from outer space and naturally occurring radioactive materials within the body. In Washington, the increased levels from Fukushima meant the daily dose during that time could have been about 16.4017. A harmful amount that would cause obvious symptoms of exposure is anywhere from two to three million microsieverts at one time, he said.
"So, you can detect the increase but being detectable does not mean it's harmful," Tipping said.
Xenon 133 is a nuclear fission product that is closely monitored at nuclear stations around the world because it can be used to determine whether a country has conducted an illegal or covert nuclear test explosion. Such tests are banned under the Comprehensive Nuclear-Test-Ban Treaty (CTBT), which was adopted by the United Nations in 1996 and created a worldwide network of nuclear monitoring stations.
Similarly to how 911 emergency centers can pinpoint the location of a cell phone call by triangulating the signal between many different cell towers, nuclear stations within the network share information on Xenon 133 and other radioactive materials to determine where they originated. The network, established as part of CTBT, is crucial to detecting clandestine nuclear tests.
The detection of the radioactive gas in Washington is significant because it demonstrates technology advancements made by Biegalski, PNNL and others, to create a more sensitive monitoring system – one that's capable of detecting extremely small amounts of the gas.
"The culmination of international research collaborations resulted in this very sensitive monitoring technology. These advancements will not only be beneficial for nuclear monitoring, they are also very beneficial to the emergency response teams called to disasters like Fukushima," said Biegalski, an expert in nuclear forensics, nuclear modeling, and nuclear monitoring, who is currently developing complex algorithms that will be used to improve the capabilities even more.
As soon as he and PNNL researchers began detecting radioactive gases in Washington, they shared the data with federal officials in the U.S. and Japan so that it could be relayed to emergency responders on the ground at Fukushima.
"As the measurements came in sooner and at higher concentrations than we initially expected, we quickly came to the conclusion that there were some major core melts at those facilities," Biegalski said. "I remember being in the lab thinking, 'Wow, if this is all true we have a far more bigger accident than what we're hearing right now."
The thought was confirmed by data collected by he and PNNL researchers. Their study reports that more radioxenon was released from the Fukushima facilities than in the 1979 meltdown at the Three Mile Island Nuclear Generating Station in Pennsylvania and in the 1986 Chernobyl nuclear disaster in the Ukraine.
Biegalski said the reason for the large release in Fukushima, when compared to the others, is that there were three nuclear reactors at the Japan facilities rather than just one.
The study was published in the Journal of Environmental Radioactivity.
Contacts and sources:
Melissa Mixon
University of Texas at Austin
"I think the conclusion was that this was a really major event here," Cockrell School of Engineering Associate Professor Steven Biegalski said of the Fukushima disaster.
Biegalski was on a faculty research assignment at PNNL in Richland, Washington. Its here that, using technology that Biegalski helped improve, he and a team of researchers were the first to detect radioactive materials from Fukushima in the U.S.
The material detected, Xenon 133, is of the same chemical family as helium and argon and is an inert gas, meaning it does not react with other chemicals. The gas is not harmful in small doses and is used medically to study the flow of blood through the brain and the flow of air through the lungs.
Tracy Tipping, a health physicist and laboratory manager at The University of Texas at Austin's Nuclear Engineering Teaching Laboratory, said the average person in the U.S. receives about 16.4 microsieverts of radiation dose per day from various sources of naturally occurring radiation, such as radioactive materials in the soil, cosmic radiation from outer space and naturally occurring radioactive materials within the body. In Washington, the increased levels from Fukushima meant the daily dose during that time could have been about 16.4017. A harmful amount that would cause obvious symptoms of exposure is anywhere from two to three million microsieverts at one time, he said.
"So, you can detect the increase but being detectable does not mean it's harmful," Tipping said.
Xenon 133 is a nuclear fission product that is closely monitored at nuclear stations around the world because it can be used to determine whether a country has conducted an illegal or covert nuclear test explosion. Such tests are banned under the Comprehensive Nuclear-Test-Ban Treaty (CTBT), which was adopted by the United Nations in 1996 and created a worldwide network of nuclear monitoring stations.
Similarly to how 911 emergency centers can pinpoint the location of a cell phone call by triangulating the signal between many different cell towers, nuclear stations within the network share information on Xenon 133 and other radioactive materials to determine where they originated. The network, established as part of CTBT, is crucial to detecting clandestine nuclear tests.
The detection of the radioactive gas in Washington is significant because it demonstrates technology advancements made by Biegalski, PNNL and others, to create a more sensitive monitoring system – one that's capable of detecting extremely small amounts of the gas.
"The culmination of international research collaborations resulted in this very sensitive monitoring technology. These advancements will not only be beneficial for nuclear monitoring, they are also very beneficial to the emergency response teams called to disasters like Fukushima," said Biegalski, an expert in nuclear forensics, nuclear modeling, and nuclear monitoring, who is currently developing complex algorithms that will be used to improve the capabilities even more.
As soon as he and PNNL researchers began detecting radioactive gases in Washington, they shared the data with federal officials in the U.S. and Japan so that it could be relayed to emergency responders on the ground at Fukushima.
"As the measurements came in sooner and at higher concentrations than we initially expected, we quickly came to the conclusion that there were some major core melts at those facilities," Biegalski said. "I remember being in the lab thinking, 'Wow, if this is all true we have a far more bigger accident than what we're hearing right now."
The thought was confirmed by data collected by he and PNNL researchers. Their study reports that more radioxenon was released from the Fukushima facilities than in the 1979 meltdown at the Three Mile Island Nuclear Generating Station in Pennsylvania and in the 1986 Chernobyl nuclear disaster in the Ukraine.
Biegalski said the reason for the large release in Fukushima, when compared to the others, is that there were three nuclear reactors at the Japan facilities rather than just one.
The study was published in the Journal of Environmental Radioactivity.
Contacts and sources:
Melissa Mixon
University of Texas at Austin
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